Identification of superficial zone articular chondrocyte stem/progenitor cells
نویسندگان
چکیده
منابع مشابه
Does the Superficial Zone of Articular Cartilage Contain Progenitor Cells?
Introduction. The regeneration capacity of cartilage in general is very limited. Cartilage does not contain blood vessels and is thought to consist of only one cell type (chondrocytes) lacking progenitor cells. The chondrocytes, laying isolated in a dense extracellular matrix, have very limited proliferation potential. Despite the absence of repair or regeneration of damaged articular cartilage...
متن کاملRemoval of the superficial zone of bovine articular cartilage does not increase its frictional coefficient.
OBJECTIVE To investigate the role of the superficial zone in regulating the frictional response of articular cartilage. This zone contains the superficial protein (SZP), a proteoglycan synthesized exclusively by superficial zone chondrocytes and implicated in reducing the friction coefficient of cartilage. DESIGN Unconfined compression creep tests with sliding of cartilage against glass in sa...
متن کاملVulnerability of the superficial zone of immature articular cartilage to compressive injury.
OBJECTIVE The zonal composition and functioning of adult articular cartilage causes depth-dependent responses to compressive injury. In immature cartilage, shear and compressive moduli as well as collagen and sulfated glycosaminoglycan (sGAG) content also vary with depth. However, there is little understanding of the depth-dependent damage caused by injury. Since injury to immature knee joints ...
متن کاملThe mechanical consequence of removing the superficial zone of articular cartilage
• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version ...
متن کاملSuperficial Zone Extracellular Matrix Extracts Enhance Boundary Lubrication of Self-Assembled Articular Cartilage.
OBJECTIVE Previous work has shown that increasing the production of boundary lubricant, superficial zone protein (SZP), did not reduce the friction coefficient of self-assembled articular cartilage constructs and was possibly due to poor retention of the lubricant. The aim of this investigation was to reduce the friction coefficient of self-assembled articular cartilage constructs through enhan...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2007
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.04.142